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TO: PSA ATHLETES and MEMBER NATIONS

WADA PROHIBITED LIST 2018

The 2018 Prohibited List will be effective 1 January 2018. As usual there are some

changes.

Below is a synopsis of the major modifications. Those of particular relevance have been

bolded. Refer to the list for the names of drugs added.

A. Substances and Methods prohibited at all times (In-and Out-of-Competition)

Prohibited Substances:

S1: Anabolic Steroids

- Renaming and some additions to the list

S2: Peptide Hormones, Growth Factors, Related Substances and Mimetics:

- Vitamin B12, which contains cobalt, is not prohibited

- Some additions to the list.

S3: Beta 2-Agonists i.e. the non-corticosteroid medication found in many asthma

inhalers (e.g. salbutamol, salmeterol, formoterol, which are not banned if taken as

per prescribed)

- Dosing parameters of salbutamol were revised to make it clear that

divided doses of salbutamol may not exceed 800 micrograms over any

12 hours. There is a maximum of 1600 micrograms over 24 hours but

not to exceed 800 micrograms over 12 hours.

- Tulobuterol was added as an example of an accepted Beta 2-Agonist

- Note: Terbutaline, which is commonly prescribed is still banned

- The statement on the urinary thresholds was improved

S4: Hormone and Metabolic Modulators

- a few additions

S5: Diuretics and Masking Agents:

- Glycerol has been removed from the list.

Prohibited Methods:

Chemical and Physical Manipulation:

M2: The permitted volume and timing of intravenous infusions were changed

from infusions of no more than 50ml per 6 hour period, to no more than

100ml per 12 hour period in order to allow greater flexibility for the safe

administration of non-prohibited therapeutic substances such as iron.

- To reflect medical practice, "hospital admission" has been changed to "hospital

treatments" and "clinical investigations" has been as "clinical diagnostic

investigations".

M3: Gene Doping

- The definition has been revised to include current and emerging gene

manipulating technologies.

Substances and Methods Prohibited In-Competition:

S6: Stimulants:

- 1,3-Dimethylbutylamine was added as an example. This substance can

be found in some dietary supplements.

S6: Cannabinoids:

- The category Cannabimimetics e.g. "Spice, JWH-018, JWH-073, HU210" was

changed to "synthetic cannabinoids e.g. tetrahydrocannabinol (THC) and other

cannabinoids".

- The synthetic cannabinoids are one of the main classes of psychoactive

substances that have constantly emerging new drugs and changing availability.

The previous list of examples continues to be prohibited, but are currently used

less commonly. "Other Cannabimimetics" replaced these examples.

- Cannabidiol is no longer prohibited. Synthetic cannabidiol is not a

cannabimimetic, however, cannabidiol extracted from cannabis plants

may also contain varying concentrations of THC, which remains a

prohibited substance.

S9: Glucocorticoids:

- Examples of commonly used glucocorticoids were added for greater

clarity.

Steroids, Stimulants, Glucocorticoids, Diuretics and contaminated stimulants are all

categories of substances a few squash athletes have used. It is critical that advice is

sought if any medication is considered for use. Always refer to the Prohibited List – if

the nomenclature of the drugs is difficult to understand, ask an expert.

Avoid any supplements. They are non-regulated, have questionable manufacturing

processes, there is no requirement for correct identification of ingredients and can easily

be contaminated with a prohibited substance.

Remember, as an athlete you and only you are responsible for what you take.

Dr Anne Smith

Chair WSF Anti-Doping Commission

SUMMARY OF MAJOR MODIFICATIONS

AND EXPLANATORY NOTES

2018 PROHIBITED LIST

Substances and methods prohibited at all times

(In- and Out-of-Competition)

Prohibited Substances

S1

ANABOLIC AGENTS

• Dihydrotestosterone was renamed to its International

Non-proprietary Name (INN) (androstanolone).

1-androsterone (3

a-hydroxy-5a-androst-1-ene-17-one)

was added in S1.a as an example of exogenous

anabolic steroid.

• LGD-4033 and RAD140 were added as further examples

of SARMs.

S2

PEPTIDE HORMONES, GROWTH

FACTORS, RELATED SUBSTANCES

AND MIMETICS

• For clarity and accuracy Section S2 was reorganized.

• ARA290 was removed as an example in this section

because current literature suggests it does not meet

inclusion criteria.

• Deslorelin, goserelin, nafarelin and triptorelin were

added as examples of 2.1.

• Growth Hormone fragments were included in 2.3 with

AOD-9604 and hGH 176-191 added as examples;

CJC-1293 was added as example of GHRH and

tabimorelin as a further example of GH secretagogue.

GHRP-1, -3, -4, and -5 were added as examples

of GHRP.

• Thymosin- ß4 and its derivatives, e. g. TB-500, were

added as example of prohibited growth factors.

• Cobalt: It is re-iterated that vitamin B12, which contains

cobalt, is not prohibited.

1

S3

BETA-2-AGONISTS

• Dosing parameters of salbutamol were revised to make

it clear that divided doses of salbutamol may not exceed

800 micrograms over any 12 hours (see figure).

Inhaled salbutamol – max. 1600 mcg over 24 hours

But not to exceed 800 mcg over any 12 hours

0 12 24

Any 12 hour period: max. 800 mcg

200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg 200 mcg

• Tulobuterol was added as an example.

• The statement on the urinary thresholds was improved.

S4

HORMONE AND METABOLIC

MODULATORS

• Clomifene is now stated by its INN.

• In the absence of an INN, the IUPAC name of GW1516,

2-(2-methyl-4-((4-methyl-2-(4-(trifluoromethyl)phenyl)

thiazol-5-yl)methylthio)phenoxy) acetic acid as well as

an alternative name (GW501516) were included.

• SR9009, a Rev-Erb-a agonist, was added as an example

of Activators of the AMP-activated protein kinase (AMPK).

S5

DIURETICS AND MASKING

AGENTS

• In consideration of the information published in

scientific articles since 2012 that particularly addresses

the ability of glycerol to influence the athlete‘s plasma

volume and parameters of the Athlete Biological

Passport (ABP), the magnitude of glycerol-derived

effects is regarded as minimal. Therefore, glycerol has

been removed from the Prohibited List.

Prohibited Methods

M2

CHEMICAL AND PHYSICAL

MANIPULATION

• M2.2: the permitted volume and timing of intravenous

infusions were changed from infusions of no more than

50 mL per 6-hour period to no more than a total of

100 mL per 12-hour period in order to allow greater

flexibility for the safe administration of non-prohibited

therapeutic substances, for example, iron.

• To reflect medical practice, "hospital admissions" has

been changed to "hospital treatments" and "clinical

investigations" has been clarified as "clinical diagnostic

investigations".

M3

GENE DOPING

• The definition has been revised to include current and

emerging gene manipulating technologies.

Substances and Methods

Prohibited In-Competition

S6

STIMULANTS

• 1,3-Dimethylbutylamine was added as an example. This

substance can be found in some dietary supplements.

2

S8

CANNABINOIDS

• The category Cannabimimetics, e.g. "Spice, JWH-018,

JWH-073, HU210" was changed to "synthetic

cannabinoids, e.g. ?9-tetrahydrocannabinol (THC) and

other cannabimimetics". The synthetic cannabinoids are

one of the main classes of novel psychoactive

substances that have constantly emerging new drugs

and changing availability. The previous list of examples

continues to be prohibited, but are currently used less

commonly. "Other cannabimimetics" replaced

these examples.

• Cannabidiol is no longer prohibited. Synthetic

cannabidiol is not a cannabimimetic; however,

cannabidiol extracted from cannabis plants may also

contain varying concentrations of THC, which remains

a prohibited substance.

S9

GLUCOCORTICOIDS

• Examples of commonly used glucocorticoids were added

for greater clarity.

Substances Prohibited

in Particular Sports

P1

ALCOHOL

• After careful consideration and extensive consultation,

Alcohol was excluded from the Prohibited List. The

intent of this change is not to compromise the integrity

or safety of any sport where alcohol use is a concern,

but rather to endorse a different means of enforcing

bans on alcohol use in these sports. The four

International Federations (IF) affected by this change

have been alerted sufficiently in advance in order to

amend their rules and to put in place protocols to test

for alcohol use and appropriately sanction athletes who

do not abide by the rules of their sport. Control of the

process will allow IF more flexibility in applying rules or

thresholds as they see fit. The National Anti-Doping

Organizations are no longer obliged to conduct tests but

may assist IF and National Federations where appropriate.

P2

BETA BLOCKERS

• For logical consistency, the category known as P2. Beta

Blockers was renamed P1. Beta Blockers.

MONITORING PROGRAM

The following were added to evaluate misuse in sport:

• 2-ethylsulfanyl-1H-benzimidazole (bemitil) in- and

out-of-competition

• Hydrocodone in-competition.

Mitragynine and telmisartan were removed from the

Monitoring Program because the required information

on prevalence was obtained.

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